A most destructive fire broke out on Wednesday morning, at four o'clock, in the house of Mr. Steward, baker, Sermon lane, Doctors' commons which soon consumed the whole of the premises. The flames were soon communicated to the adjoining houses, and four of them, immediately contiguous to that in which the fire originated, are now little else but a pile of ruins. The greater part of the property was destroyed, but happily there were no lives lost.